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[Kinetic analysis of interaction of human immunodeficiency virus reverse transcriptase with alkaloids]




 

Mol Biol (Mosk). 1994 Nov-Dec;28(6):1308-14. Unique Identifier :

The interactions of HIV-I reverse transcriptase with some alkaloids were studied. Among nine compounds tested three--berberine, palmatine and sanguiritrine--inhibited RT. The dependence of the inhibition on the type of template-primer was also demonstrated. The kinetic analysis as well as circular dichroism experiments suggest the complex mechanism of RT inhibition by alkaloids. This mechanism includes both enzyme-alkaloid and alkaloid-template interactions; the latter effect also results in RT inhibition.

Alkaloids/*PHARMACOLOGY Berberine/PHARMACOLOGY Berbines/PHARMACOLOGY Circular Dichroism English Abstract HIV-1/*ENZYMOLOGY Kinetics RNA-Directed DNA Polymerase/*ANTAGONISTS & INHIB JOURNAL ARTICLE



 




Information in this article was accurate in June 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.