effect of hyperbaric oxygen on tissue distribution of mononuclear cell subsets in the rat.

NLM AIDSLINE Effect of hyperbaric oxygen on tissue distribution of mononuclear cell subsets in the rat. Bitterman N; Lahat N; Rosenwald T; Kinarty A; Melamed Y; Bitterman H;
June 30, 1995

J Appl Physiol. 1994 Nov;77(5):2355-9. Unique Identifier : AIDSLINE In a previous study we found a significant temporary decrease in the ratio of CD4/CD8 (helper, inducer/suppressor, cytotoxic) T lymphocytes in the peripheral blood of healthy human volunteers after exposure to a single commonly used profile of hyperbaric oxygen (HBO). The transient nature of the changes suggested redistribution of T-cell subsets. The purpose of the present study was to verify such a redistribution and to locate possible target organs in an animal model. A single exposure of rats to HBO (0.28 MPa) induced a highly significant rapid decrease in the CD4/CD8 ratio in peripheral blood count (P < 0.0001), confirming our previous findings in humans. HBO also induced a significant increase in the CD4/CD8 ratio in the lungs and lymph nodes (P < 0.001) and a significant decrease in the ratio in the spleen (P < 0.01). Furthermore, exposure to HBO induced a significant increase in T cells bearing surface interleukin-2 receptors in the blood, spleen, lungs, and lymph glands (P < 0.001) and a significant decrease in T cells expressing alpha beta-receptors in the lungs (P < 0.001) and lymph glands (P < 0.05). Our findings suggest rapid T-cell activation after a brief exposure to HBO, with shifts of CD4 and CD8 subsets and variations in T-cell receptor type. These rapid changes in the parameters of cell-mediated immunity may represent the activation of protective mechanisms against the toxic effect of oxygen or the early stages of pulmonary oxygen toxicity. Animal Comparative Study CD4-CD8 Ratio Hyperbaric Oxygenation Leukocyte Count Leukocytes, Mononuclear/IMMUNOLOGY Lung/IMMUNOLOGY Lymphoid Tissue/IMMUNOLOGY Male Microscopy, Fluorescence Oxygen/PHARMACOLOGY Rats Rats, Sprague-Dawley Support, Non-U.S. Gov't T-Lymphocyte Subsets/IMMUNOLOGY JOURNAL ARTICLE

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Information in this article was accurate in June 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.