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Protection by attenuated simian immunodeficiency virus in macaques against challenge with virus-infected cells [see comments]


Lancet. 1995 May 27;345(8961):1342-4. Unique Identifier : AIDSLINE

A vaccine against AIDS will probably have to protect against challenge both by viable virus-infected cells and by cell-free virus. Eight cynomolgus macaques infected with attenuated simian immunodeficiency virus (SIV) were challenged (four each) with cell-free and cell-associated SIV. All were protected, whereas eight controls were all infected after challenge. These findings show that live-attenuated vaccine can confer protection against SIV in macaques. Extrapolation to human beings will require extensive evaluation of the safety of attenuated retroviruses. Alternatively, the mechanism of this potent protection must be understood and reproduced by less hazardous means.

Animal Antibodies, Viral/ANALYSIS AIDS Vaccines Disease Models, Animal Genes, nef/GENETICS Human Macaca fascicularis Mutation/GENETICS Simian Acquired Immunodeficiency Syndrome/*PREVENTION & CONTROL Support, Non-U.S. Gov't *SAIDS Vaccines *SIV/GENETICS *Vaccines, Attenuated JOURNAL ARTICLE


Information in this article was accurate in August 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.