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Herpesvirus-like DNA sequences in non-Kaposi's sarcoma skin lesions of transplant patients.


Lancet. 1995 May 27;345(8961):1339-40. Unique Identifier : AIDSLINE

Herpesvirus-like DNA sequences (KSHV) have been reported to be associated with various forms of Kaposi's sarcoma (KS). To determine if KSHV was associated with other proliferative skin lesions from non-AIDS immunocompromised patients, 33 skin lesions (basal cell carcinomas, squamous cell carcinomas, actinic keratoses, verruca vulgaris, atypical squamous proliferations, and seborrhoeic keratosis) from 4 organ-transplant patients receiving immunosuppressive therapy were tested for KSHV by PCR. KSHV sequences were detected in 82% of these skin lesions. Our results suggest that KSHV is associated with lesions other than KS in non-AIDS immunocompromised patients, and may also be involved in the pathogenesis of the various forms of proliferative skin lesions from organ-transplant patients.

*Base Sequence Carcinoma, Basal Cell/GENETICS/VIROLOGY Carcinoma, Squamous Cell/GENETICS/VIROLOGY Dermatitis, Seborrheic/GENETICS/VIROLOGY DNA, Viral/ANALYSIS/*GENETICS Gene Expression Regulation, Viral Globin/ANALYSIS/GENETICS Herpesviridae/*GENETICS Human Immunocompromised Host Keratosis/GENETICS/VIROLOGY *Organ Transplantation Polymerase Chain Reaction Sarcoma, Kaposi's/GENETICS/VIROLOGY Skin Diseases/GENETICS/*VIROLOGY Skin Neoplasms/GENETICS/*VIROLOGY Warts/GENETICS/VIROLOGY JOURNAL ARTICLE


Information in this article was accurate in August 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.