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Human immunodeficiency virus (HIV) type 1 infection status and in vitro susceptibility to HIV infection among high-risk HIV-1-seronegative hemophiliacs.


J Infect Dis. 1995 Jul;172(1):228-31. Unique Identifier : AIDSLINE

Blood samples were obtained from 16 hemophiliacs who had a 50%-94% defined risk of human immunodeficiency virus (HIV) type 1 infection on the basis of treatment history and from 14 controls not at risk for HIV infection. HIV-1 was not detected in any of 12 patient samples by cocultivation nor in 14 patient samples by the polymerase chain reaction. Peripheral blood cells from 7 seronegative hemophiliacs at highest risk of seroconversion (94%) were less susceptible to HIV-1 infection in vitro than were cells from healthy controls (P < .025, one-tailed Wilcoxon rank sum test). In contrast, the susceptibility to HIV-1 infection of lymphocytes from 6 seronegative hemophiliacs at moderate risk (50%-56%) of seroconversion did not differ from that of cells from controls or from high-risk hemophiliacs. Therefore, prolonged periods of seronegative HIV-1 infection are not common in this high-risk population. In addition, among hemophiliacs there may exist heterogeneity in susceptibility to HIV-1 infection in vitro and in vivo.

Adult Comparative Study CD4 Lymphocyte Count CD8-Positive T-Lymphocytes/IMMUNOLOGY Disease Susceptibility Factor IX/ANALYSIS Factor VIII/ANALYSIS Hemophilia/BLOOD/*COMPLICATIONS/IMMUNOLOGY Human HIV Infections/*EPIDEMIOLOGY/TRANSMISSION *HIV Seronegativity HIV Seropositivity/*IMMUNOLOGY *HIV-1/GENETICS/ISOLATION & PURIF Lymphocyte Count Male Polymerase Chain Reaction Risk Factors Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE


Information in this article was accurate in October 30, 1995. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.