Natl Conf Hum Retroviruses Relat Infect (1st). 1993 Dec 12-16;:142.
To determine the utility of bone marrow aspirate examination (BMAE) for
the diagnosis of opportunistic infections and lymphoma in HIV-infected
patients, we retrospectively reviewed the records of all patients
undergoing diagnostic BMAE at one AIDS reference center in Madrid, Spain
between April 1991 and June 1993. Specimens were examined cytologically
and microbiologically for opportunistic pathogens or lymphoma. A total
of 186 specimens have been analyzed. Suspicion of Mycobacterial
'granulomatous' images were recognized in 24% of cases, and positive
Mycobacterial cultures were achieved in 44% of them Mycobacterium avium
complex infections were three times more frequent than tuberculosis.
Leishmania amastigotes were seen in 11% of cases, and Visceral
leishmaniasis was confirmed in all of them. Lymphoma was suspected in
10%, and later confirmed in 80% of them. Fungal infections
(histoplasmosis) were diagnosed in 2 (1%) of patients because BMAE was
performed mostly for fever of unknown origin and/or non-explained
cytopenia, we concluded that BMAE is a rapid and accurate method for
diagnosing OI and lymphomas in HIV-infected patients.
Adult Aged Biliary Tract Diseases/*COMPLICATIONS Female Hepatitis,
Viral, Human Human HIV Infections/*COMPLICATIONS Liver
Diseases/*COMPLICATIONS Male Middle Age Prospective Studies Serology