Natl Conf Hum Retroviruses Relat Infect (1st). 1993 Dec 12-16;:132.
Increases in the proportion and absolute number of particular CD8 cell
subset phenotypes, which express membrane activation markers such as
CD38 and DR, have been correlated both with progressive clinical stages
of HIV disease and with risk for progression in asymptomatic patients.
To determine whether CD8 cell subsets have any prognostic value in the
patient population with advanced HIV infection, 83 patients in ACTG
Protocol 181 from 3 study sites were evaluated for T cell subsets and
followed up to 15 months for the occurrence of AIDS-defining clinical
events and survival. Patients received PCP prophylaxis and continued
with long-term antiretroviral therapy (median 18 mo. prior AZT). At
study entry, week 4, and subsequent 3- month intervals, blood samples
were analyzed for standard CD4 and CD8 cell subsets and for the
phenotypes CD8/DR+, CD8/CD38+, CD8/S6F1+, and CD3/CD16+56+. Preliminary
data analysis has been performed on a subgroup of 20 patients. As
expected, low CD4 cell values were correlated with increased risk for
clinical progression. Additional data trends indicated that a higher
rate of AIDS-defining events was associated with the initial presence of
lower proportions of the CD8/DR+ and the CD8/CD38+ cell subsets, and
elevated percentages of CD3/CD16+56+ cells. Data analysis on the entire
study cohort is in progress and will be included for presentation.
Human HIV Infections/*DRUG THERAPY Ontario Physician's Practice
Patterns Zidovudine/*THERAPEUTIC USE ABSTRACT