Rev Med Chil. 1995 Jan;123(1):74-80. Unique Identifier : AIDSLINE
An acute clinical picture of variable intensity may occur during the
initial primary phase of HIV infection, it may however pass unnoticed.
We report 12 seronegative subjects (11 male homosexuals, 1 female
heterosexual, aged 18 to 44 years old), that presented an acute clinical
picture preceding seroconversion. All had a sudden beginning, resembling
an acute mononucleosis in 10 and with an aseptic meningitis in two.
Intensity and duration were variable, lasting a mean of 14 (range 5-44)
days an remaining asymptomatic thereafter. Most patients presented a
discrete leukopenia with lymphopenia at the expense of CD4 lymphocytes,
followed by an absolute lymphocytosis in some, with an increase in CD8
lymphocytes. All became positive for HIV; circulating HIV antigen was
identified in three and IgM anti-HIV antibodies were detected during the
symptomatic period by third generation ELISA in other three. It is
concluded that the clinical picture of primary HIV infection has
identifiable clinical serological and immunological features and its
recognition has diagnostic and preventive implications.
Adolescence Adult AIDS Serodiagnosis CD4-Positive
T-Lymphocytes/IMMUNOLOGY CD8-Positive T-Lymphocytes/IMMUNOLOGY English
Abstract Female Follow-Up Studies Human HIV
Infections/DIAGNOSIS/*IMMUNOLOGY Male Support, Non-U.S. Gov't JOURNAL