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[Incidence and differential diagnosis of cholestasis in AIDS--a retrospective analysis of 73 patients]


Z Gastroenterol. 1993 Feb;31 Suppl 2:126-8. Unique Identifier : AIDSLINE

A significant cholestasis constellation (alk. phosphatase and GGT each increased to twice as much as the norm) in 73 consecutive patients with AIDS was found in the course of the disease in 29 patients (= 39.7%). In most of the patients advanced immunodeficiency with an average of 2.5 AIDS-defining diseases already existed. In the predominant number of cases it was intrahepatic cholestasis with only slight icterus. Therapeutic measures such as medicamentous treatment or high-caloric parenteral nutrition were causal in two thirds of the cases; in a quarter of the cases opportunistic infections, above all disseminating mycobacteriosis were found. One third of the patients had already existing liver diseases. Liver biopsy frequently proved diagnostic and should be performed more often in the case of unclear liver findings in AIDS patients.

Acquired Immunodeficiency Syndrome/*DIAGNOSIS/DRUG THERAPY/ PATHOLOGY Adult Aged Anti-Infective Agents/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS AIDS-Related Opportunistic Infections/DIAGNOSIS/DRUG THERAPY/ PATHOLOGY Cholestasis, Intrahepatic/CHEMICALLY INDUCED/*DIAGNOSIS/PATHOLOGY Diagnosis, Differential English Abstract Female Human Liver/PATHOLOGY Liver Function Tests Male Middle Age Retrospective Studies JOURNAL ARTICLE


Information in this article was accurate in February 28, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.