Resource Logo
NLM AIDSLINE

Vitamin E supplementation with interferon-gamma administration retards immune dysfunction during murine retrovirus infection.




 

J Leukoc Biol. 1995 Dec;58(6):698-703. Unique Identifier : AIDSLINE

Murine retrovirus infection induces loss of vitamin E and immune dysfunction with loss of cytokine production by T-helper cells. Therefore interferon-gamma (IFN-gamma) was given during dietary vitamin E supplementation to effectively prevent murine retrovirus-induced immunosuppression, cytokine dysregulation, and development of murine AIDS. Administration of IFN-gamma during vitamin E supplementation significantly prevented development of retrovirus-induced suppression of splenic natural killer cell activity and T cell proliferation. It also significantly slowed retrovirus-induced elevation of T helper (Th) 2 cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine (IL-6 and tumor necrosis factor-alpha) secretion by splenocytes. The treatment also prevented loss of Th1 cytokine (IL-2 and IFN-gamma) secretion by splenocytes from retrovirus-infected mice alleviating splenomegaly and hypergammaglobulinemia. The combined therapy had an additive therapeutic impact. It was more effective than IFN-gamma treatment or vitamin E supplementation alone in delaying the development of retrovirus-induced immunosuppression with its cytokine dysregulation.

Animal B-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY Cytokines/BIOSYNTHESIS Female Immune Tolerance/DRUG EFFECTS Interferon Type II/*PHARMACOLOGY Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY Lymphocyte Transformation/DRUG EFFECTS Mice Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. Vitamin E/METABOLISM/*PHARMACOLOGY JOURNAL ARTICLE



 




Information in this article was accurate in March 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.