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Vitamin E supplementation with interferon-gamma administration retards immune dysfunction during murine retrovirus infection.


J Leukoc Biol. 1995 Dec;58(6):698-703. Unique Identifier : AIDSLINE

Murine retrovirus infection induces loss of vitamin E and immune dysfunction with loss of cytokine production by T-helper cells. Therefore interferon-gamma (IFN-gamma) was given during dietary vitamin E supplementation to effectively prevent murine retrovirus-induced immunosuppression, cytokine dysregulation, and development of murine AIDS. Administration of IFN-gamma during vitamin E supplementation significantly prevented development of retrovirus-induced suppression of splenic natural killer cell activity and T cell proliferation. It also significantly slowed retrovirus-induced elevation of T helper (Th) 2 cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine (IL-6 and tumor necrosis factor-alpha) secretion by splenocytes. The treatment also prevented loss of Th1 cytokine (IL-2 and IFN-gamma) secretion by splenocytes from retrovirus-infected mice alleviating splenomegaly and hypergammaglobulinemia. The combined therapy had an additive therapeutic impact. It was more effective than IFN-gamma treatment or vitamin E supplementation alone in delaying the development of retrovirus-induced immunosuppression with its cytokine dysregulation.

Animal B-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY Cytokines/BIOSYNTHESIS Female Immune Tolerance/DRUG EFFECTS Interferon Type II/*PHARMACOLOGY Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY Lymphocyte Transformation/DRUG EFFECTS Mice Mice, Inbred C57BL Murine Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. Vitamin E/METABOLISM/*PHARMACOLOGY JOURNAL ARTICLE


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