J Leukoc Biol. 1995 Dec;58(6):698-703. Unique Identifier : AIDSLINE
Murine retrovirus infection induces loss of vitamin E and immune
dysfunction with loss of cytokine production by T-helper cells.
Therefore interferon-gamma (IFN-gamma) was given during dietary vitamin
E supplementation to effectively prevent murine retrovirus-induced
immunosuppression, cytokine dysregulation, and development of murine
AIDS. Administration of IFN-gamma during vitamin E supplementation
significantly prevented development of retrovirus-induced suppression of
splenic natural killer cell activity and T cell proliferation. It also
significantly slowed retrovirus-induced elevation of T helper (Th) 2
cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine
(IL-6 and tumor necrosis factor-alpha) secretion by splenocytes. The
treatment also prevented loss of Th1 cytokine (IL-2 and IFN-gamma)
secretion by splenocytes from retrovirus-infected mice alleviating
splenomegaly and hypergammaglobulinemia. The combined therapy had an
additive therapeutic impact. It was more effective than IFN-gamma
treatment or vitamin E supplementation alone in delaying the development
of retrovirus-induced immunosuppression with its cytokine dysregulation.
Animal B-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY Cytokines/BIOSYNTHESIS
Female Immune Tolerance/DRUG EFFECTS Interferon Type II/*PHARMACOLOGY
Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY Lymphocyte
Transformation/DRUG EFFECTS Mice Mice, Inbred C57BL Murine Acquired
Immunodeficiency Syndrome/*IMMUNOLOGY Support, U.S. Gov't, P.H.S.
Vitamin E/METABOLISM/*PHARMACOLOGY JOURNAL ARTICLE