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The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical applications.




 

J Leukoc Biol. 1995 Dec;58(6):634-42. Unique Identifier : AIDSLINE

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.

Acquired Immunodeficiency Syndrome/THERAPY Anemia, Aplastic/THERAPY Bone Marrow Transplantation Granulocyte-Macrophage Colony-Stimulating Factor/ADVERSE EFFECTS/ *PHARMACOLOGY/THERAPEUTIC USE Hematopoiesis/*DRUG EFFECTS Human Monocytes/*DRUG EFFECTS Neutrophils/*DRUG EFFECTS Signal Transduction Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL



 




Information in this article was accurate in March 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.