altered in vitro handling of mycobacterium avium complex by monocytes and serum from hiv(+) patients.

NLM AIDSLINE Altered in vitro handling of Mycobacterium avium complex by monocytes and serum from HIV(+) patients. Swartz RP; Roecklein JA; Pierce PF Jr; Yeager H Jr; Department of
May 30, 1996

Immunol Invest. 1995 Nov;24(6):987-98. Unique Identifier : AIDSLINE In patients with acquired immunodeficiency syndrome (AIDS), mycobacterial diseases are leading opportunistic infections. The reasons for the peculiar propensity for disseminated infection with Mycobacterium avium complex (MAC) remain unclear. We have previously examined, in detail, the ability of monocytes from healthy donors to take up and kill MAC under both nonopsonic and opsonic conditions. We have now evaluated the in vitro ability of peripheral blood monocytes from HIV(+) patients to take up and kill MAC organisms, and have discovered a reduced ability under both nonopsonic and opsonic conditions. This reduction is due to: 1) apparent defect(s) in the phagocytes themselves, and 2) substance(s) in the HIV(+) serum which actively suppresses phagocyte activity. Adult Blood Bactericidal Activity/DRUG EFFECTS Cells, Cultured Female Glucans/PHARMACOLOGY Human HIV Seronegativity HIV Seropositivity/BLOOD/MICROBIOLOGY Male Middle Age Monocytes/MICROBIOLOGY/VIROLOGY Mycobacterium avium Complex/*IMMUNOLOGY Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE

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Information in this article was accurate in May 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.