Muscle Nerve. 1996 Jun;19(6):722-7. Unique Identifier : AIDSLINE
We performed quantitative immunohistochemical studies of sural nerve
biopsy specimens from 20 patients to determine whether endoneurial and
epineurial lymphocytic infiltration occurs in diabetic nerves. The
diabetic nerves contained a mean of 129 CD3+ cells per tissue section
compared to 19 cells in patients with chronic neuropathy matched for the
histologic severity of disease, and 0-5 cells in normal control nerves.
The T-cell infiltrates in the diabetic nerves were predominantly of the
CD8+ cell type. Activated endoneurial lymphocytes expressed
immunoreactive cytokines and major histocompatibility class II antigens.
Microvasculitis was found in 12 (60%) patients. Infiltrative T cells may
contribute to the pathogenesis of diabetic neuropathy through a variety
of effector mechanisms.
Aged Aged, 80 and over Antigens, CD3/ANALYSIS Biopsy CD8-Positive
T-Lymphocytes/IMMUNOLOGY/PATHOLOGY Demyelinating Diseases/PATHOLOGY
Diabetes Mellitus, Insulin-Dependent/IMMUNOLOGY/PHYSIOPATHOLOGY
Diabetes Mellitus, Non-Insulin-Dependent/IMMUNOLOGY/ PHYSIOPATHOLOGY
Diabetic Neuropathies/IMMUNOLOGY/*PATHOLOGY Female Follow-Up Studies
Human Immunoglobulins/ANALYSIS Immunohistochemistry/METHODS
Male Middle Age Nerve Fibers/PATHOLOGY/ULTRASTRUCTURE Support,
Non-U.S. Gov't Sural Nerve/IMMUNOLOGY/*PATHOLOGY JOURNAL ARTICLE