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[Low incidence of non-Hodgkin lymphoma but high seroprevalence of HTLV-I in Curacao]


Ned Tijdschr Geneeskd. 1996 May 25;140(21):1119-22. Unique Identifier :

OBJECTIVE. To determine whether the low incidence of non-Hodgkin's lymphoma (NHL) in Curacao has changed in comparison with the increase in incidence in many western countries, and to investigate the role of the HTLV-I infection that is endemic in the Caribbean area. DESIGN. Retrospective. SETTING. Curacao, Netherlands Antilles. METHOD. Retrospective file analysis in the only hospital in Curacao. RESULTS. During the period 1987-1992, 31 patients had a histologically confirmed diagnosis of NHL resulting in an annual incidence rate of 4.9/100,000 adults. There was a strong age-related increase in NHL incidence rate (0.5 for patients < 30 years to 17.8 for patients > or = 70 years), with a male to female ratio of I. (In the western world the incidence is 12-14, in the seventies it was 4.5 in Curacao.) Seven of 12 patients (58%) tested were seropositive for HTLV-I. Median survival was 6 months, despite conventional therapy. CONCLUSION. While HTLV-I infection can often be demonstrated in NHL patients in Curacao, NHL incidence has remained low over the past 25 years.

Adolescence Adult Aged Demography English Abstract Female Human HTLV-I Infections/*EPIDEMIOLOGY Incidence Lymphoma, Non-Hodgkin's/*EPIDEMIOLOGY Male Middle Age Netherlands Antilles/EPIDEMIOLOGY Retrospective Studies Seroepidemiologic Methods JOURNAL ARTICLE


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