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Drug leads from the Kallawaya herbalists of Bolivia. 1. Background, rationale, protocol and anti-HIV activity.


J Ethnopharmacol. 1996 Mar;50(3):157-66. Unique Identifier : AIDSLINE

Aqueous, organic and alcoholic extracts of over 100 samples of 60 species of Kallawaya medicinal herbs representing 30 plant families were assayed to compare their toxicity and ability to protect MT-2 T-lymphoblastoid cells from the cytopathic effect of human immunodeficiency virus (HIV). The results are reported as a therapeutic index (TI) which was > 25 for eighteen species, including seven > 50 and one > 100. The anti-HIV activity resided primarily in the aqueous rather than in the organic extracts and was concentrated in plants used in ethnomedicine to treat lung and liver diseases.

Acquired Immunodeficiency Syndrome/*DRUG THERAPY Alcohols/CHEMISTRY Bolivia Cell Survival/DRUG EFFECTS Human HIV/*DRUG EFFECTS Liver Diseases/DRUG THERAPY Lung Diseases/DRUG THERAPY *Medicine, Herbal Plant Extracts/PHARMACOLOGY/TOXICITY/THERAPEUTIC USE *Plants, Medicinal/METABOLISM Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. T-Lymphocytes/DRUG EFFECTS/VIROLOGY JOURNAL ARTICLE


Information in this article was accurate in October 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.