il-7 up-regulates hiv-1 replication in naturally infected peripheral blood mononuclear cells.

NLM AIDSLINE IL-7 up-regulates HIV-1 replication in naturally infected peripheral blood mononuclear cells. Smithgall MD; Wong JG; Critchett KE; Haffar OK; Bristol-Myers Squibb
October 30, 1996

J Immunol. 1996 Mar 15;156(6):2324-30. Unique Identifier : AIDSLINE We have investigated the effect of exogenous IL-7 on replication of HIV-1 in PBMCs isolated from asymptomatic, chronically infected donors. We show that IL-7 induced virus replication and increased proviral DNA levels in CD8- PBMC cultures. IL-7 also increased the levels of doubly spliced HIV-1 tat RNA in these cultures. In comparison, IL-2 induced lower levels of virus production than IL-7, but had a more pronounced effect on cell proliferation. The IL-7-mediated increase in virus replication was not inhibited by neutralizing mAbs to IL-1 beta, IL-2, IL-6, or TNF-alpha, and was only partially dependent on ligation of the T cell accessory molecule CD28. CD8+ cells inhibited the increase in viral replication following IL-7 stimulation, but did not prevent virus replication following ligation of CD3 in the presence of IL-7. The data shows that IL-7 regulates HIV-1 replication in naturally infected PBMCs. Antigens, CD28/METABOLISM/PHYSIOLOGY Cells, Cultured Cytokines/ANTAGONISTS & INHIB CD8-Positive T-Lymphocytes/IMMUNOLOGY Genes, tat/DRUG EFFECTS Human HIV Infections/IMMUNOLOGY/VIROLOGY HIV-1/DRUG EFFECTS/IMMUNOLOGY/PHYSIOLOGY Interleukin-7/PHARMACOLOGY Leukocytes, Mononuclear/IMMUNOLOGY/VIROLOGY RNA, Messenger/BIOSYNTHESIS Virus Inhibitors/IMMUNOLOGY Virus Replication/DRUG EFFECTS/IMMUNOLOGY JOURNAL ARTICLE

Most Read: Latest Added Related Topics White House LGBT Conference on HIV/AIDS UNITED STATES: White House in Atlanta: LGBT AIDS Conference No more single-theme conferences: global HIV prevention conference planned FHI 360 Senior Scientist Lut Van Damme Receives International Microbicide Conference Lifetime Achievement Award Equatorial Guinea Ministry of Health and Social Welfare and UNICEF Refute Erroneous AIDS Prevalence Figures Photographs from A Day with HIV Now Online Bulgaria urges Libya to investigate AIDS nurses case Engineers enter fight against AIDS in Africa Gilead’s Complera® Non-Inferior to Atripla® Among Treatment-Naive HIV Patients UN chief Ban calls world leaders to end Aids by 2020 CALIFORNIA: Over Half of People Living with AIDS in San Francisco Are Aged 50 or Older THAILAND; UNITED STATES: HIV Drug Can Also Protect Injection Drug Users INDONESIA: Growing HIV/AIDS Awareness in Indonesia's Papua Region UNITED STATES: Many Young Americans Unaware They're Infected with HIV Board to Vote on Condoms in Boston Schools New International Report on HIV Prevention Urges Localized Consideration of Antiretroviral Strategies UNAIDS and Lancet to bring together political and health leaders to shape the debate on the future of global health Cambodia Trains Social Workers to Curb Reliance on Foreign Aid New Hampshire nears approval of medical marijuana law Celebrating 10 years of PEPFAR THAILAND; UNITED STATES: HIV Drug Can Also Protect Injection Drug Users INDONESIA: Growing HIV/AIDS Awareness in Indonesia's Papua Region UNITED STATES: Many Young Americans Unaware They're Infected with HIV New International Report on HIV Prevention Urges Localized Consideration of Antiretroviral Strategies New Analysis of World's Premier AIDS Conference Finds Poor Coverage of Populations Most-at-Risk for HIV GREECE: Doubled HIV Cases Add to Greek Woes OHIO: Phila Health Department HIV Testing Well-Received CONNECTICUT: City's Circle Care Center is a Model for HIV Prevention TAIWAN: HIV/AIDS Spreading to Younger People in Taiwan FLORIDA: Groups Offering Free HIV Testing
Information in this article was accurate in October 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.