ongoing and future trials of antiretroviral therapy in the pediatric aids clinical trials group (pactg).

NLM AIDSLINE Ongoing and future trials of antiretroviral therapy in the pediatric AIDS clinical trials group (PACTG). McKinney RE Jr; Duke University Medical Center, Durham, NC.
November 30, 1996

3rd Conf Retro and Opportun Infect. 1996 Jan 28-Feb 1;:173. Unique The Pediatric AIDS Clinical Trials Group is a multi-center collaborative group sponsored by NIAID and NICHD. Clinical trials of antiretroviral therapy are one important objective of the organization. Current Phase III trials include ACTG 300 [Zidovudine (ZDV) + Lamivudine (3TC) vs. ZDV + Didanosine (ddI) vs. ddI monotherapy in antiretroviral treatment naive children], ACTG 239 [ddI vs. ZDV + ddI in HIV infected infants less than or equal to 2 months old], ACTG 240 [ZDV vs. Stavudine (D4T) in antiretroviral naive children less than or equal to 6 years old], and ACTG 245 [ZDV + ddI vs. ddI + Nevirapine (NVP) vs. ZDV +ddI +NVP in previously treated children with advanced HIV disease]. Phase I studies are underway or in development for 3TC + ZDV in infants (ACTG 321); for Adefovir dipivoxil (bis-POM PMEA) (ACTG 310); for ddI plus Ribavirin (ACTG 274); and for 1592U89 (a nucleoside analog RT inhibitor). An ongoing Perinatal Prophylaxis trial, ACTG 185, compares ZDV to ZDV + HIV-specific immune globulin (HIVIg). Phase I studies of NVP (ACTG 250) and ddI (ACTG 249) in pregnancy are open to accrual. A template-based protocol is being designed to expedite the virologic evaluation of combination regimens and new antiretroviral drugs in HIV infected children. Acquired Immunodeficiency Syndrome/DRUG THERAPY Antiviral Agents/ADMINISTRATION & DOSAGE/THERAPEUTIC USE Child Child, Preschool Clinical Trials Clinical Trials, Phase I Clinical Trials, Phase II Clinical Trials, Phase III Drug Therapy, Combination Human Infant ABSTRACT

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Information in this article was accurate in November 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.