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C-reactive protein (CRP) versus erythrocyte sedimentation rate (ESR) as indicators of acute bacterial infections in febrile human immunodeficiency- virus (HIV)-infected children.


3rd Conf Retro and Opportun Infect. 1996 Jan 28-Feb 1;:157. Unique

Objective: Determine if CRP is a more useful diagnostic test than ESR in assessing for potential bacterial infections in HIV infected children. Methods : Prospective analysis of CRP and ESR were taken from 31 HIV-infected children , ages ranging from 2 months to 19 years, presenting with possible bacterial infection. CRP and ESR were done as diagnostic tests along with white blood cell count and differential, bacterial cultures, viral studies, and radiological assessment as clinically indicated. Results: Of the 31 infected children, 45 encounters were recorded. There were 23 bacterial illnesses and 22 viral illnesses diagnosed. The CRP was elevated in over half of the bacterial iIlnesses. In the viral illnesses less than 25% had elevaled CRP, whereas the ESR was elevated in nearly all cases of both viral and bacterial infections. The ESR appears to remain elevated in HIV-infected children regardless of the clinical illness being of bacterial or viral origin. The CRP corresponds to the presence of bacterial infection. We suggest that the CRP can serve as a screening test in HIV-infected children, thus reducing hospitalizations and/or unnecessary antibiotic treatment. Clearly, this is a preliminary study and larger number of patients need to be evaluated.

Adolescence Adult Bacterial Infections/COMPLICATIONS/*PHYSIOPATHOLOGY *Blood Sedimentation C-Reactive Protein/*METABOLISM Child Child, Preschool Fever/*ETIOLOGY HIV Infections/*COMPLICATIONS Human Infant Prospective Studies ABSTRACT


Information in this article was accurate in November 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.