distribution of prolyl oligopeptidase in human peripheral tissues and body fluids.

NLM AIDSLINE Distribution of prolyl oligopeptidase in human peripheral tissues and body fluids. Goossens F; De Meester I; Vanhoof G; Scharpe S; Laboratorium voor
November 30, 1996

Eur J Clin Chem Clin Biochem. 1996 Jan;34(1):17-22. Unique Identifier : Prolyl oligopeptidase (EC 3.4.21.26) activity was measured in human tissue homogenates and body fluids. The enzyme was ubiquitously present, revealing high activity in renal cortex, epithelial cells, fibroblasts, testis, lymphocytes and thrombocytes. The activity in the body fluids was low. Prolyl oligopeptidase activity was significant higher in tumours of prostate, lung and sigmoid, than in the healthy tissues. Sera of individuals suffering from HIV infection, malaria, prostate cancer or benign prostate hypertrophy contained lowered activity. Interestingly, the low serum activity during prostate carcinoma increased upon medical treatment with anti-androgens. This suggests hormonal control of the gene transcript. A positive correlation with angiotensin converting enzyme activity in hypertensive patients was demonstrated and this further supports the possible involvement of prolyl oligopeptidase in the renin-angiotensin system and in the pathogenesis of hypertension. Acquired Immunodeficiency Syndrome/ENZYMOLOGY Amino Acid Sequence Body Fluids/ENZYMOLOGY Female Human Hypertension, Renal/ENZYMOLOGY Lung Neoplasms/ENZYMOLOGY Malaria/ENZYMOLOGY Male Molecular Sequence Data Peptidyl-Dipeptidase A/ANALYSIS Prostatic Hyperplasia/ENZYMOLOGY Prostatic Neoplasms/ENZYMOLOGY Serine Proteinases/ANALYSIS Support, Non-U.S. Gov't Tissue Distribution JOURNAL ARTICLE

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Information in this article was accurate in November 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.