clinicians views of hiv clinical drug trials.

NLM AIDSLINE Clinicians views of HIV clinical drug trials. Hales G; Beveridge A; Smith D; Kippax S; Community HIV Research Network,
December 30, 1996

Annu Conf Australas Soc HIV Med. 1995 Nov 16-19;7:114 (abstract no. OBJECTIVE: Treatments for HIV with greater efficacy are currently being sought through clinical trials. If a trial shows one treatment is effective, those on the other arm will have received suboptimal therapy for the duration of the trial. The focus of this study was to examine the dichotomy of roles for the clinician, who is both physician and investigator. METHOD: General Practitioners and Hospital doctors participating in a international phase II clinical drug trial were interviewed and asked to discuss their attitudes and concerns about clinical drug trials. Their role as investigator versus clinician was also examined. RESULTS: The interviews were analysed thematically. All the doctors shared the belief that trials are necessary and important but that there are conflicts between the needs of the individual and collecting data which is reliable and can be generalised. Other issues discussed were the patient's motives for participation and compliance. The doctors also expressed concerns regarding the selection and withdrawal of subjects as well as the effects of trials on their relationship with patients. CONCLUSION: Effective treatments in HIV are desired by both patient and clinician. The current means of assessing new therapies can cause dilemmas for the doctors involved. Attitude of Health Personnel Clinical Trials Clinical Trials, Phase II Human HIV Infections/DRUG THERAPY Medical Staff, Hospital Patient Compliance Patient Participation *Physician's Role Physicians, Family ABSTRACT

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Information in this article was accurate in December 30, 1996. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.