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HIV viremia influences survival in HIV-infected patients.


Int Conf AIDS. 1996 Jul 7-12;11(2):27 (abstract no. We.B.413). Unique

Objective: To assess if HIV viremia influences survival and clinical progression. Methods: 398 patients who had frozen plasma collected between 1991-93 were selected after stratification by baseline CD4 cell counts (0-49, 50-199, 200-499, and greater than or equal to 500 /mm3). Outcome variables were death and onset of opportunistic infections. Baseline predictors were HIV viremia Roche Amplicor), CD4 cell counts, and clinical stages. Data were analyzed using the Kaplan-Meier method and proportional hazards models. Results: The sample included 309 men and 89 women, aged 18 to 66 years (mean 35, SD 8). During a mean follow-up of 27 months, 160 patients died: survival was 85% after 1 year and 69% after 2 years. At baseline, the log HIV RNA ranged from 2.00 to 6.24 (mean 4.34, SD 0.80) and CD4 cell counts from 2 to 1606/mm3 mean 299, SD 302); 158 patients were in stage A, 116 in stage B and 124 in stage C. These 3 parameters were independently associated with the risk of death (Table). Data on incidence of opportunistic infections will be presented. (table: see text) Conclusion: HIV viremia is a predictor of death independently of CD4 cell counts and clinical stages.



Information in this article was accurate in January 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.