Int Conf AIDS. 1996 Jul 7-12;11(2):27 (abstract no. We.B.413). Unique
Objective: To assess if HIV viremia influences survival and clinical
progression. Methods: 398 patients who had frozen plasma collected
between 1991-93 were selected after stratification by baseline CD4 cell
counts (0-49, 50-199, 200-499, and greater than or equal to 500 /mm3).
Outcome variables were death and onset of opportunistic infections.
Baseline predictors were HIV viremia Roche Amplicor), CD4 cell counts,
and clinical stages. Data were analyzed using the Kaplan-Meier method
and proportional hazards models. Results: The sample included 309 men
and 89 women, aged 18 to 66 years (mean 35, SD 8). During a mean
follow-up of 27 months, 160 patients died: survival was 85% after 1 year
and 69% after 2 years. At baseline, the log HIV RNA ranged from 2.00 to
6.24 (mean 4.34, SD 0.80) and CD4 cell counts from 2 to 1606/mm3 mean
299, SD 302); 158 patients were in stage A, 116 in stage B and 124 in
stage C. These 3 parameters were independently associated with the risk
of death (Table). Data on incidence of opportunistic infections will be
presented. (table: see text) Conclusion: HIV viremia is a predictor of
death independently of CD4 cell counts and clinical stages.
*HIV/ISOLATION & PURIF *HIV Infections/MORTALITY *RNA, Viral/ANALYSIS