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NLM AIDSLINE

[Structural and functional analysis of the human immunodeficiency glycoprotein gp120 with homologous synthetic peptides]




 

Vestn Ross Akad Med Nauk. 1996;(8):9-12. Unique Identifier : AIDSLINE

The purpose of the study was to identify sites of gp 120, which are responsible for CD4 binding and induce tumor necrosis factor-alpha (TNF-alpha) synthesis. Seven peptides were synthesized from gp 120. The peptides were studied in the following biological tests: binding to CD4 molecules of the Jurkat cell clones 3G6 and PBMC of healthy persons. There was TNF-alpha induction in healthy and HIV-positive individuals and its correlation was found with p24 antigenemia in HIV patients. The peptides 420-440, 426-452, 369-384, 255-272 bind to T-lymphocytic CD4 and induced TNF-alpha. The peptide 436-451 binds to CD4, but failed to induced TNF-alpha, which suggests that the latter may be used as a basis for HIV-infection vaccine.

Antigens, CD4/METABOLISM English Abstract Human HIV Envelope Protein gp120/*CHEMISTRY/*PHYSIOLOGY HIV Infections/METABOLISM *HIV-1 Protein Binding Tumor Necrosis Factor/METABOLISM JOURNAL ARTICLE



 




Information in this article was accurate in February 28, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.