Vestn Ross Akad Med Nauk. 1996;(8):9-12. Unique Identifier : AIDSLINE
The purpose of the study was to identify sites of gp 120, which are
responsible for CD4 binding and induce tumor necrosis factor-alpha
(TNF-alpha) synthesis. Seven peptides were synthesized from gp 120. The
peptides were studied in the following biological tests: binding to CD4
molecules of the Jurkat cell clones 3G6 and PBMC of healthy persons.
There was TNF-alpha induction in healthy and HIV-positive individuals
and its correlation was found with p24 antigenemia in HIV patients. The
peptides 420-440, 426-452, 369-384, 255-272 bind to T-lymphocytic CD4
and induced TNF-alpha. The peptide 436-451 binds to CD4, but failed to
induced TNF-alpha, which suggests that the latter may be used as a basis
for HIV-infection vaccine.
Antigens, CD4/METABOLISM English Abstract Human HIV Envelope Protein
gp120/*CHEMISTRY/*PHYSIOLOGY HIV Infections/METABOLISM *HIV-1 Protein
Binding Tumor Necrosis Factor/METABOLISM JOURNAL ARTICLE