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Immunologic and molecular characteristics of Encephalitozoon-like microsporidia isolated from humans and rabbits indicate that Encephalitozoon cuniculi is a zoonotic parasite.


Clin Infect Dis. 1996 Mar;22(3):557-9. Unique Identifier : AIDSLINE

To assess the zoonotic potential of Encephalitozoon-like microsporidia, we isolated and cultivated spores from specimens of urine, respiratory secretions, and stool from six patients infected with human immunodeficiency virus and from nine rabbits. Because spores of Encephalitozoon-like species are indistinguishable by microscopy, we characterized the isolates by western blot analysis and by restriction enzyme analysis of the small subunit (SSU) rDNA after amplification by the polymerase chain reaction. We identified Septata intestinalis in one patient and Encephalitozoon hellem in two symptomatic patients. Encephalitozoon cuniculi was found in all rabbits and in three patients. One of these patients had clinical manifestations of infection with this parasite (severe interstitial pneumonitis). We observed abatement of symptoms and cessation of parasite excretion when these patients were treated with albendazole. Our findings suggest that E. cuniculi may be pathogenic in humans and that it is a zoonotic parasite.

Animal Antigens, Protozoan/*ANALYSIS AIDS-Related Opportunistic Infections/COMPLICATIONS/*PARASITOLOGY Encephalitozoon cuniculi/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF Encephalitozoonosis/COMPLICATIONS/*PARASITOLOGY Female Human Male Rabbits RNA, Protozoan/*ANALYSIS Zoonoses JOURNAL ARTICLE


Information in this article was accurate in February 28, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.