Clin Infect Dis. 1996 Mar;22(3):557-9. Unique Identifier : AIDSLINE
To assess the zoonotic potential of Encephalitozoon-like microsporidia,
we isolated and cultivated spores from specimens of urine, respiratory
secretions, and stool from six patients infected with human
immunodeficiency virus and from nine rabbits. Because spores of
Encephalitozoon-like species are indistinguishable by microscopy, we
characterized the isolates by western blot analysis and by restriction
enzyme analysis of the small subunit (SSU) rDNA after amplification by
the polymerase chain reaction. We identified Septata intestinalis in one
patient and Encephalitozoon hellem in two symptomatic patients.
Encephalitozoon cuniculi was found in all rabbits and in three patients.
One of these patients had clinical manifestations of infection with this
parasite (severe interstitial pneumonitis). We observed abatement of
symptoms and cessation of parasite excretion when these patients were
treated with albendazole. Our findings suggest that E. cuniculi may be
pathogenic in humans and that it is a zoonotic parasite.
Animal Antigens, Protozoan/*ANALYSIS AIDS-Related Opportunistic
cuniculi/GENETICS/IMMUNOLOGY/*ISOLATION & PURIF
Encephalitozoonosis/COMPLICATIONS/*PARASITOLOGY Female Human Male
Rabbits RNA, Protozoan/*ANALYSIS Zoonoses JOURNAL ARTICLE