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NLM AIDSLINE

Protozoal colonization of the intestinal tract in institutionalized Romanian children.




 

Clin Infect Dis. 1996 Mar;22(3):456-61. Unique Identifier : AIDSLINE

To determine the prevalence of intestinal parasitic infections in 92 Romanian children institutionalized at Colentina Hospital (Bucharest, Romania) and at the Dystrophic Center (Vidra, Romania), medical charts were reviewed and complete physical examinations were performed. The nutritional status of each child was evaluated, and their sera were tested for the presence of antibodies to human immunodeficiency virus (HIV) and Cryptosporidium. Fecal samples were collected in 10% formalin and examined by an immunofluorescent assay and by trichrome staining for intestinal parasites. At least one protozoan was identified in 77% of the fecal specimens examined. Giardia lamblia (72% of cases), Cryptosporidium parvum (12%), and Entamoeba coli (4%) were the only parasites identified. Stepwise logistic regression revealed that the only factors predictive of giardia colonization were normal nutritional status (P < .01) and HIV seropositivity (P < .02), while cryptosporidium colonization was only associated with where the children lived (P < .01). Seventy-three percent of the children had IgA and/or IgG antibodies to Cryptosporidium in their sera. The presence of these antibodies was strongly associated with the severity of symptoms present in the HIV-infected children (P < .01). Protozoal colonization of the intestinal tract is common in institutionalized Romanian children and may play a role in causing morbidity and mortality in this high-risk group of children.

Animal Antibodies, Protozoan/BLOOD AIDS-Related Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY/ *PARASITOLOGY Child, Preschool Cryptosporidiosis/COMPLICATIONS/IMMUNOLOGY/PARASITOLOGY Cryptosporidium/IMMUNOLOGY/ISOLATION & PURIF Cryptosporidium parvum/IMMUNOLOGY/*ISOLATION & PURIF/METABOLISM Diarrhea/COMPLICATIONS/IMMUNOLOGY/*PARASITOLOGY Dysentery, Amebic/COMPLICATIONS/IMMUNOLOGY/PARASITOLOGY Entamoeba/*ISOLATION & PURIF/METABOLISM Feces/PARASITOLOGY Female Giardia lamblia/*ISOLATION & PURIF/METABOLISM Giardiasis/COMPLICATIONS/IMMUNOLOGY/PARASITOLOGY Human HIV-1/IMMUNOLOGY IgA/BLOOD IgG/BLOOD Infant Intestinal Diseases, Parasitic/COMPLICATIONS/IMMUNOLOGY/ *PARASITOLOGY Male Nutrition Disorders/COMPLICATIONS Romania Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. JOURNAL ARTICLE



 




Information in this article was accurate in February 28, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.