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NLM AIDSLINE

Idiopathic esophageal ulceration in patients infected with human immunodeficiency virus.




 

J Assoc Acad Minor Phys. 1996;7(4):93-8. Unique Identifier : AIDSLINE

Esophageal disease is a common and important cause of morbidity and mortality in patients with human immunodeficiency virus (HIV) infection. The etiology of HIV-related esophageal ulceration varies. After all known etiologies are excluded, a subgroup of patients remains with esophageal ulceration known as idiopathic esophageal ulceration (IEU). Establishing a diagnosis of IEU is critical and precludes unnecessary treatment with antiviral, antifungal, or antibiotic agents. A review of the current literature indicates that there are no prospective, placebo-controlled, randomized, double-blind trials on the specific treatment of IEU. Several preliminary reports suggest that corticosteroids and thalidomide may be effective. The incidence and natural history of IEU are incompletely known. It is important to establish that any potential therapeutic agents employed to treat IEU do not increase viral replication or provide viral protection. There is a need for well-designed, placebo-controlled, prospective studies to assess the risks and benefits of corticosteroids, thalidomide, and other agents in the treatment of idiopathic esophageal ulceration.

Adrenal Cortex Hormones/THERAPEUTIC USE *Esophageal Diseases/EPIDEMIOLOGY/ETIOLOGY/THERAPY Female Human HIV Infections/*COMPLICATIONS Male Prevalence Prognosis Risk Factors Ulcer/DRUG THERAPY/EPIDEMIOLOGY/*ETIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL



 




Information in this article was accurate in March 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.