epidemiology of cryptococcosis in france: a 9-year survey (1985-1993). french cryptococcosis study group.

NLM AIDSLINE Epidemiology of cryptococcosis in France: a 9-year survey (1985-1993). French Cryptococcosis Study Group. Dromer F; Mathoulin S; Dupont B; Laporte A; Centre National de Reference
March 30, 1997

Clin Infect Dis. 1996 Jul;23(1):82-90. Unique Identifier : AIDSLINE We analyzed the data collected during a nationwide survey of cryptococcosis (1985-1993). We first checked the quality of the survey. The stability of its completeness (approximately 50%) and its representativity were assessed by the capture-recapture method after we cross-checked our data on cryptococcosis (as a presenting manifestation of AIDS) against those of the national registry of AIDS. Of the 1,057 cases of cryptococcosis (1,013 patients), 827 (86%) involved patients with AIDS. The increasing number of cases of human immunodeficiency virus (HIV)-related cryptococcosis over time paralleled the AIDS epidemic except for a higher male-to-female ratio. Malignancies (32%), organ transplantation (19%), and corticosteroid therapy (33%) were the main predisposing conditions in 163 patients without AIDS. Cryptococcal meningitis more frequently occurred in patients with AIDS than in HIV-negative patients (P < 10(-6)). Among the 413 isolates available for serotyping, 410 were Cryptococcus neoformans variety neoformans (including 20.5% of serotype D). Three isolates of the variety gattii (serotype B) were recovered from patients without AIDS. Adolescence Adult Aged Antifungal Agents/THERAPEUTIC USE AIDS-Related Opportunistic Infections/COMPLICATIONS/EPIDEMIOLOGY/ MICROBIOLOGY Child Cryptococcosis/COMPLICATIONS/*EPIDEMIOLOGY/MICROBIOLOGY Cryptococcus neoformans/CLASSIFICATION/ISOLATION & PURIF Data Collection Evaluation Studies Female France/EPIDEMIOLOGY Human Male Middle Age Questionnaires Retrospective Studies Serotyping Time Factors JOURNAL ARTICLE

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Information in this article was accurate in March 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.