Intervirology. 1996;39(3):165-75. Unique Identifier : AIDSLINE
Persistent human polyomavirus infection is asymptomatic with limited
states of virus production in the healthy individual, in
immunocompromised patients, however, infection may lead to uncontrolled
virus growth and fatal disease. Predominantly the CNS and in rare cases
the urogenital tract are affected. During the AIDS epidemic, the number
of cases is steadily increasing, thus dictating the need for an early
and fast differential diagnosis. Virological diagnosis is essentially
based on the detection of virus products in tissue or body fluids.
Although sensitive and specific diagnostic techniques are available for
the diagnosis of polyomavirus infection, widely accepted standards are
not yet reached. This is in part due to the low number of cases in the
past, but also to asymptomatic viral activation in nondiseased patients.
Thus, additional parameters have to be evaluated to provide
complementary tools for differential diagnosis.
*Leukoencephalopathy, Progressive Multifocal/DIAGNOSIS *Papovaviridae
Infections/DIAGNOSIS *Polyomavirus hominis 1/ISOLATION & PURIF
*Polyomavirus hominis 2/ISOLATION & PURIF *Tumor Virus