J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Apr 1;14(4):374-9.
Thrombocytopenia in persons infected with HIV is prevalent and has
numerous causes. To study the occurrence, associations, and effect on
survival of thrombocytopenia in HIV-infected persons, we used
surveillance data from a longitudinal survey of the medical records of
30,214 HIV-infected patients who received medical care from January 1990
through August 1996 in more than 100 medical clinics in 10 U.S. cities.
Thrombocytopenia was defined as a physician diagnosis of
thrombocytopenia or a platelet count of < 50,000 platelets/ microliter.
Analysis of associations of thrombocytopenia was conducted using
logistic regression. In HIV+ patients, the 1-year incidence [corrected]
of thrombocytopenia was 8.7% in persons with one or more AIDS-defining
opportunistic illnesses (clinical AIDS), 3.1% in patients with a CD4
count < 200 cells/mm3 but not clinical AIDS immunologic AIDS), and 1.7%
in persons without clinical or immunologic AIDS. The incidence of
thrombocytopenia was associated with clinical AIDS (adjusted odds ratio
[AOR] 2.2; 99% confidence interval [CI] 1.7-3.0), immunologic AIDS (AOR
1.5, CI 1.0-2.1), history of injecting drug use (AOR 1.4, CI 1.0-1.9),
anemia (AOR 5.0, CI 3.8-6.7), lymphoma (AOR 3.7, CI 1.3-10.6), and black
race (AOR 0.7, CI 0.5-0.9). After controlling for anemia, clinical AIDS,
CD4 count, neutropenia, antiretroviral therapy, and Pneumocystis carinii
pneumonia prophylaxis, thrombocytopenia was significantly associated
with decreased survival (risk ratio 1.7; 95% CI, 1.6-1.8).
Thrombocytopenia in HIV-infected persons is an important clinical
condition associated with shorter survival.
*HIV Infections/COMPLICATIONS *Thrombocytopenia/COMPLICATIONS