[tuberculous hepatosplenic abscess, human immunodeficiency virus infection and multiresistant tuberculosis]

NLM AIDSLINE [Tuberculous hepatosplenic abscess, human immunodeficiency virus infection and multiresistant tuberculosis] Valencia ME; Moreno V; Soriano V; Laguna F; Adrados M; Ortega A; March
July 30, 1997

Rev Clin Esp. 1996 Dec;196(12):816-20. Unique Identifier : AIDSLINE BACKGROUND: Tuberculosis (TB) with liver and/or spleen abscess HSA) formation in HIV-positive patients is uncommon. PATIENTS AND METHODS: One hundred and thirty-seven HIV positive patients with TB were studied from January 93 to June 95. Patients with tuberculous HSA were enrolled in the study. Diagnosis was obtained by recovery of Mycobacterium tuberculosis in clinical specimens and the presence of hypoechogenic lesions in liver and/or spleen. RESULTS: M. tuberculosis isolates were resistant to some of the usual drugs in 51 patients. Twenty of these patients had HSA (39%) and in 18 patients the antibiotic sensitivity testing showed resistance to isoniazid, rifampin, ethambutol, and streptomycin. The remaining 86 patients had episodes of TB with drug-susceptible microorganism and only three patients had HSA (3%) (p < 0.001). The 23 patients with tuberculous HSA had a mean CD4+ lymphocyte count of 33 x 10(6) cells/L (2-111) and 7 had a previous episode of TB. The abdominal echography showed hepatosplenomegaly in all cases. Abscesses were located at the liver in 12 patients (52%), spleen in 18 (78%) and both organs in 7 (30%). In 16 cases a corticosteroid therapy was indicated. In the 3 patients with susceptible TB and HSA the clinical course was good. The 20 patients with resistant TB died. CONCLUSION: Abdominal TB in HIV-positive patients and HSA formation appears to be more common in severely immunosuppressed patients, with resistant TB and its mortality rate is high. The response to therapy with antituberculous drugs is slow and sometimes the administration of corticosteroids is necessary for the resolution of symptoms. HIV Seropositivity/COMPLICATIONS Liver Abscess/COMPLICATIONS Splenic Diseases/COMPLICATIONS Tuberculosis, Hepatic/COMPLICATIONS Tuberculosis, Multidrug-Resistant/COMPLICATIONS Tuberculosis, Splenic/COMPLICATIONS

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Information in this article was accurate in July 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.