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Differential requirements for survival and proliferation of CD8 naive or memory T cells [see comments]


Science. 1997 Jun 27;276(5321):2057-62. Unique Identifier : AIDSLINE

The requisite molecular interactions for CD8 T cell memory were determined by comparison of monoclonal naive and memory CD8(+) T cells bearing the T cell receptor (TCR) for the HY antigen. Naive T cells required only the right major histocompatibility complex (MHC) class I-restricting molecule to survive; to expand, they also needed antigen. In contrast, for survival, memory cells did not require the restricting MHC allele, but needed only a nonspecific class I; for expansion the correct class I, but not antigen, was required. Thus, maintenance of CD8 T cell memory still required TCR-MHC class I interactions, but memory T cells may have a lower functional activation threshold that facilitates secondary responses.

*CD8-Positive T-Lymphocytes/IMMUNOLOGY *Immunologic Memory *T-Lymphocyte Subsets/IMMUNOLOGY


Information in this article was accurate in September 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.