Science. 1997 Jun 27;276(5321):2057-62. Unique Identifier : AIDSLINE
The requisite molecular interactions for CD8 T cell memory were
determined by comparison of monoclonal naive and memory CD8(+) T cells
bearing the T cell receptor (TCR) for the HY antigen. Naive T cells
required only the right major histocompatibility complex (MHC) class
I-restricting molecule to survive; to expand, they also needed antigen.
In contrast, for survival, memory cells did not require the restricting
MHC allele, but needed only a nonspecific class I; for expansion the
correct class I, but not antigen, was required. Thus, maintenance of CD8
T cell memory still required TCR-MHC class I interactions, but memory T
cells may have a lower functional activation threshold that facilitates
secondary responses.
*CD8-Positive T-Lymphocytes/IMMUNOLOGY *Immunologic Memory
*T-Lymphocyte Subsets/IMMUNOLOGY