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An animal model for acute and persistent Epstein-Barr virus infection.


Science. 1997 Jun 27;276(5321):2030-3. Unique Identifier : AIDSLINE

Epstein-Barr virus (EBV) is a human lymphocryptovirus that causes infectious mononucleosis, persists asymptomatically for life in nearly all adults, and is associated with the development of B cell lymphomas and nasopharyngeal carcinomas. A highly similar rhesus lymphocryptovirus naturally endemic in rhesus monkeys was used to orally infect naive animals from a pathogen-free colony. This animal model reproduced key aspects of human EBV infection, including oral transmission, atypical lymphocytosis, lymphadenopathy, activation of CD23(+) peripheral blood B cells, sustained serologic responses to lytic and latent EBV antigens, latent infection in the peripheral blood, and virus persistence in oropharyngeal secretions. This system may be useful for studying the pathogenesis, prevention, and treatment of EBV infection and associated oncogenesis.

*Disease Models, Animal *Herpesviridae Infections/IMMUNOLOGY *Herpesviridae Infections/PATHOLOGY *Herpesviridae Infections/VIROLOGY *Herpesvirus 4, Human *Lymphocryptovirus/IMMUNOLOGY *Lymphocryptovirus/ISOLATION & PURIF *Macaca mulatta *Tumor Virus Infections/IMMUNOLOGY *Tumor Virus Infections/PATHOLOGY *Tumor Virus Infections/VIROLOGY


Information in this article was accurate in September 30, 1997. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.