Acta Paediatr Jpn. 1997 Oct;39(5):556-8. Unique Identifier : AIDSLINE
Eight Japanese hemophiliacs with chronic hepatitis C (CHC) received
interferon (IFN) therapy and four of them (50%) responded completely.
Non-responders included 3 double-infected patients: 1 with hepatitis B
virus (HBV) and 2 with human immunodeficiency virus-1 (HIV-1). In one of
the patients with HIV-1 double infection, the absolute number of CD4+
lymphocytes decreased during IFN therapy. These findings suggest that
hemophiliac patients with CHC can respond well to IFN therapy, but in
patients who are double-infected with HBV and HIV-1, the indication of
IFN therapy should be considered seriously.
*HIV-1 *Hemophilia/COMPLICATIONS *Hepatitis C/THERAPY *Hepatitis,
Chronic/THERAPY *Interferon-beta/THERAPEUTIC USE