Wiad Parazytol. 1997;43(2):179-83. Unique Identifier : AIDSLINE
Mice received 5 ng of ricin 24 hours after infection (experiment I) or 1
ng of ricin twice, 24 hours and 17 days of infection experiment II).
Animals were killed in 7, 14, 21, 28, 35, 42 and 60 days after
infection. In the jejunum and masseter muscle sections, CD4+ and CD8+
lymphocytes, mast cells and eosinophils were studied. Heavy suppression
of CD8+ lymphocytes, strong eosinophils and less pronounced mast cells
stimulation was observed in the jejunum of mice received ricin
(experiment I). Worm expulsion in intestine was faster than in the
control opposite results in experiment II). The composition of cells
infiltration in the muscle was in both experiments similar to the
control, however, fewer CD4+ lymphocytes were observed in larva capsule
and there were fewer muscle larvae. Therefore CD8+ cells are believed to
take part in restricting only the muscle stage of trichinellosis.
*Intestinal Diseases, Parasitic/DRUG THERAPY *Ricin/THERAPEUTIC USE
*Trichinella spiralis/DRUG EFFECTS *Trichinosis/DRUG THERAPY