Rev Med Chil. 1997 Jan;125(1):95-8. Unique Identifier : AIDSLINE
Renal involvement in AIDS may be specific or unspecific. Unspecific
lesions, the most common, are usually an acute tubular necrosis produced
by hemodynamic, infectious or electrolytic alterations that lead to an
acute renal failure or drug nephrotoxicity. Specific lesions are
segmental and focal hyalinosis, immune complex glomerulonephritis and
thrombotic microangiopathy. Focal and segmental hyalinosis is observed
almost exclusively in black people and produces a rapidly progressive
renal failure. Lesions are a consequence of HIV stimulation of TGF beta
in mesangial cells. Immune complex glomerulonephritis, formed by HIV
antigens and anti HIV antibodies, is observed in white and black people.
The glomerular lesion in this condition is less severe than in the
former. Thrombotic microangiopathy could be a consequence of a
pathogenic effect of the virus over glomerular capillaries and
arterioles. It is clinically expressed as a hemolytic uremic syndrome.
This paper reports briefly the renal pathological study of 46 patients
infected with HIV-1, seen at the Nephrology Service of the Bichat
Hospital in Paris.
*AIDS-Associated Nephropathy/COMPLICATIONS *HIV