J Clin Lab Immunol. 1995;46(1):35-40. Unique Identifier : AIDSLINE
It is accepted that T cells play a critical role during virus
infections; however, T cell responses in vivo in acute stage of virus
infection are not understood. We examined T cell activation in vivo in
two volunteers who developed dengue fever in response to vaccination
with a candidate live dengue vaccine. Serial plasma collected from the
volunteers from day 0 (before infection) to day 17 after infection were
examined for levels of soluble interleukin-2 receptor (sIL-2R), soluble
CD4 (sCD4), soluble CD8 (sCD8), interleukin-2 (IL-2) and interferon
gamma INF gamma). Elevation of the levels of sIL-2R, IFN gamma, sCD4 and
IL-2 became obvious during the period of viremia and was followed by a
later increase in the level of sCD8. The levels of IFN gamma and sIL-2R
declined after the end of the period of viremia. These results indicate
that i. T cells are activated in vivo by dengue virus infection ii.
activation of CD4+ T cells occurs during the period of viremia iii.
activation of CD8+ T cells follows CD4+ T cell activation. These results
suggest that activation of T cells in vivo may contribute to controlling
acute dengue virus infections.
*Dengue/IMMUNOLOGY *Lymphocyte Transformation