nonsymmetrically substituted cyclic urea hiv protease inhibitors.

NLM AIDSLINE Nonsymmetrically substituted cyclic urea HIV protease inhibitors. Wilkerson WW; Dax S; Cheatham WW; DuPont Merck Pharmaceutical Company,
March 30, 1998

J Med Chem. 1997 Dec 5;40(25):4079-88. Unique Identifier : AIDSLINE A series of nonsymmetrically substituted cyclic ureacarboxamides was synthesized and evaluated for antiviral activity as a function of the inhibition of HIV-protease. Selected protease inhibitors were also evaluated for oral bioavailability. The synthesis, pharmacology, quantitative structure-activity relationship (QSAR), and pharmacokinetics for the series will be discussed. Anti-HIV Agents/CHEMICAL SYNTHESIS HIV Protease Inhibitors/CHEMICAL SYNTHESIS *Urea/CHEMICAL SYNTHESIS

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Information in this article was accurate in March 30, 1998. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.