J Pediatr Gastroenterol Nutr. 1997 Aug;25(2):182-7. Unique Identifier :
BACKGROUND: Enteric cryptosporidiosis is a frequent problem in adults
with human immunodeficiency virus (HIV) infection, but little is known
of its features in children. The aim of this study was to investigate
the incidence and the clinical features of cryptosporidiosis in
HIV-infected children. METHODS: Thirty-five children with symptomatic
HIV infection were screened every 2 months, and in case of diarrhea, for
the presence of Cryptosporidium. Intestinal function tests were
performed, and the fecal osmotic gap was measured in children with
cryptosporidiosis. RESULTS: Seventy episodes of diarrhea occurred in 16
children in a median period of 17 months. Cryptosporidium was detected
in five cases, all with full-blown acquired immunodeficiency syndrome.
Cryptosporidiosis was significantly more protracted than any other form
of diarrhea and was associated with dehydration and severe weight loss.
Intestinal function was not modified during cryptosporidiosis. Osmotic
gap values were consistent with secretory rather than osmotic diarrhea.
In four cases, recovery was observed without specific treatment.
CONCLUSIONS: Enteric cryptosporidiosis is a severe problem in advanced
stages of HIV infection. It does not induce intestinal malabsorption. It
induces diarrhea of secretory type. Recovery may be observed
independently of therapy.
*Cryptosporidiosis/EPIDEMIOLOGY *Diarrhea/PARASITOLOGY *HIV
Infections/COMPLICATIONS *Intestinal Diseases, Parasitic/EPIDEMIOLOGY