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NFATc promotes completion of HIV-1 reverse-transcription events and viral replication in primary CD4+ T cells.


HIV Pathog Treat Conf. 1998 Mar 13-19;:40 (abstract no. 1008). Unique

Productive infection of primary T cells by HIV-1 is dependent upon the status of T cell activation. Post-entry, furtherance of HIV-1 replication in T cells requires overcoming blockades at one of several intracellular locales. Current data suggests that overcoming this blockade is dependent upon host intracellular events that are induced concomitant with T cell activation. We demonstrate here that a member of the nuclear factor of activated T cells (NFAT/Rel) family, NFATc/NFAT2 allows the completion of production HIV-1 infection in primary CD4+ T cells, overcoming the blockade. In the absence of NFATc, reverse transcription terminates in primary T cells at a step prior to 1st strand transfer. Exogenous expression of NFATc in primary T cells suffices to allow efficient and complete reverse transcription and the establishment of productive HIV-1 infection. Thus, productive HIV-1 infection of primary T cells is controlled by host cellular factors, such as NFATc. Therefore, these host cellular factors are possible targets for future anti-HIV-1 therapy.

MEETING ABSTRACTS CD4-Positive T-Lymphocytes/IMMUNOLOGY/*VIROLOGY DNA-Binding Proteins/*METABOLISM HIV-1/*GENETICS/PHYSIOLOGY Lymphocyte Transformation Transcription Factors/*METABOLISM *Transcription, Genetic Virus Replication/*PHYSIOLOGY


Information in this article was accurate in December 30, 1998. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.