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Cervical neoplasia and condylomata in a cohort of HIV-1 infected women.


Int Conf AIDS. 1998;12:1179 (abstract no. 60980). Unique Identifier :

OBJECTIVE: to estimate the prevalence of HPV-Cervical intraepithelial neoplasia (CIN) lesions and condylomata in cohort of HIV seropositive women observed from January 1993 to february 1997. PATIENTS AND METHODS: Gynecological examination, colposcopy with biopsy and immunological parameters were performed on 110 women patients consecutively observed. The mean age was 31.2 yrs; 42 patients were intravenous drug addicts, 63 had heterosexual contacts and 5 were transfused. Out of 63 heterosexual patients 70% had had only one sexual partner. 48 (43.6%) patients were on category A; 62 were symptomatic: 35 were on category B and 27 on C. 65/110 patients were under treatment with antiretroviral compounds. RESULTS: At the time of enrollment HPV-CIN lesions were found in 21/110 patients (19.1%) and condylomata in 12/110 patients (10.9%). CIN I lesions were present in 6, CIN II in 8 and CIN III in 7 out 21 patients. 18 out of 21 patients were symptomatic (7 on category B and 11 on category C) and 17/21 reported only one sexual partner. Visual or colposcopic inspection of genital tract demonstrated that condylomata were present on vulva (4 patients), portal (6 patients), vagina and anus (2 patients) respectively. CONCLUSIONS: The prevalence of HPV-CIN lesions and condylomata in our cohort is in agreement with the data of other studies, but worthwhile is that in our cohort 71.1% of the heterosexual women had had only one sexual partner so being considered not at high risk of HIV infection and HPV-CIN lesions.

MEETING ABSTRACTS Adult Anti-HIV Agents/THERAPEUTIC USE Blood Transfusion/ADVERSE EFFECTS Cervix Neoplasms/*COMPLICATIONS/EPIDEMIOLOGY/VIROLOGY Cohort Studies Condylomata Acuminata/*COMPLICATIONS/EPIDEMIOLOGY/VIROLOGY Female Human HIV Infections/*COMPLICATIONS/DRUG THERAPY HIV-1 Papillomavirus, Human/ISOLATION & PURIF Prevalence Sexual Partners Substance Abuse, Intravenous


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