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Potential use of cost of treatment and quality of life data for decision making in antiretroviral therapy.


Int Conf AIDS. 1998;12:1080 (abstract no. 60435). Unique Identifier :

OBJECTIVES: Assessment of quality of life and cost of treatment in HIV/AIDS. DESIGN: Prospective follow-up of patients in a single institution in Northern Germany. METHODS: This study analyses quality of life and cost of treatment data from an outpatient-clinic a the University Hospital in Hannover, Germany. Measures include SELT and EUROQUOL questionnaires for quality of life assessment. Additionally multidimensional questionnaires and patient documentation are being used for cost evaluation in this ongoing project. In an attempt to assess cost-effectiveness of ART, we linked quality of life scores to various antiretroviral combination therapies. RESULTS: The quality of life instrument showed no significant difference between various ART combinations. However, quadruple combination therapy (1) yielded clearly higher QOL scores in CDC C3 patients than all triple combinations (2) (Wilcoxon Rank Sum W test: Mean of QOL scores of 77.60 (1) (n = 4, SD = 5,762) versus 62.97 (2) (n = 25, SD = 115,842); p = 0.0499; 95% confidence interval). This advantage in quality of life does not outweigh the additional cost. Average yearly cost of triple therapy was 25,950 DM (41,190 per QUALY), as compared to 38,200 DM (49,230 per QUALY) for quadruple therapy. Further information will derive from the growing number of interviews. CONCLUSION: Quality of life data may inform decision making in HIV/AIDS therapy. In the context of transition of HIV infection from an acute fatal disease to a more or less chronic condition, resources shift from long inpatient stays to more aggressive ART. These expensive long-term therapies will necessitate further cost-effectiveness studies.

MEETING ABSTRACTS Anti-HIV Agents/*THERAPEUTIC USE Cost-Benefit Analysis *Decision Making Follow-Up Studies Germany Human Prospective Studies *Quality of Life Questionnaires


Information in this article was accurate in December 30, 1998. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.