Int Conf AIDS. 1998;12:1017 (abstract no. 60091). Unique Identifier :
OBJECTIVES: To evaluate the prevalence of antibodies to Toxoplasma
gondii in HIV infected individuals in Pune, India. DESIGN: A
prospective, controlled study from Feb.-May. 1997. METHODS: Patients
attending our HIV clinic over four months were recruited irrespective of
their clinical status. Paired Sera were screened for toxoplasma
antibodies using two Enzyme Linked Immunosorbent Assay (ELISA) kits.
Lymphocyte phenotyping were done by flow cytometry. HIV negative matched
controls were recruited and toxoplasma serology determined. RESULTS: A
total of 79 subjects and controls were recruited. Seroprevalence of
toxoplasma in HIV infected subjects and controls is 63.6% and 64.3%
respectively (p > 0.05). Age, sex, immunological and clinical status did
not have a significant impact on seroprevalence, however higher
toxoplasma titres were seen amongst HIV infected subjects. Higher titres
were also noted amongst symptomatic HIV infected patients. CONCLUSION:
This is the highest reported toxoplasma seroprevalence rates in India.
Without adequate prophylaxis and progressive immunodeficiency a large
amount of HIV infected individuals will develop clinical toxoplasmosis.
Routine screening for toxoplasma serology amongst HIV infected
individuals is recommended so that prophylaxis can be instituted when
immunosuppresion sets in.
MEETING ABSTRACTS Antibodies, Protozoan/*BLOOD AIDS-Related
Opportunistic Infections/*EPIDEMIOLOGY/IMMUNOLOGY Cross-Sectional
Studies *Developing Countries Human Incidence India/EPIDEMIOLOGY
Prospective Studies Toxoplasmosis/*EPIDEMIOLOGY/IMMUNOLOGY