Int Conf AIDS. 1998;12:1004 (abstract no. 60010). Unique Identifier :
OBJECTIVES: To describe the preliminary results of the Chinese herbal
XQ-9302 effect against HIV-1. DESIGN: Both in vitro and in clinic.
METHODS: XQ-9302 is a highly-purified, precise mixture of 20 Chinese
herbs in powered form. The investigation included i) Anti-HIV-1 in vitro
on MT4 cells. ii) Analysis of 27 types of metal elements. iii) Safety
and immune response of the XQ-9302 among HIV infections. iv) Pilot
clinic trial: 6 adult patients with confirmed HIV infection and active
wasting syndrome, OIs and an obvious drop of CD4 were observed. They
took the herbs for 9-12 months. HIV Load as well as HIV culture, P24
antigen, HIV antibody, CD4 counts, etc, were periodically tested.
RESULTS: A total of 10 batches of the herbs tested in vitro showed 50%
of the protection to MT4 cells from the attack of 100 TCID50 HIV-1 at
the concentration of 0.147-0.216 mg/ml. No metals excedded the limit. 40
people had no side-effects after long-term use and CD4 counts increased
in an average 200-400. The HIV load among the patients was decreased
more than 1 log. The Chinese Herbal Formula XQ-9302 could not only slow
development of the disease and improve body immunity but also interrupt
the virus replication either in vitro and in clinic. In addition, the
herbs are safe and the level of the metal elements meets with
concentration limits.
MEETING ABSTRACTS CLINICAL TRIAL Acquired Immunodeficiency
Syndrome/*DRUG THERAPY Adult Anti-HIV Agents/*THERAPEUTIC USE China
CD4 Lymphocyte Count/DRUG EFFECTS Drugs, Chinese Herbal/*THERAPEUTIC
USE Human HIV Wasting Syndrome/DRUG THERAPY HIV-1/*DRUG EFFECTS
Pilot Projects Viral Load