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Sickle cell anaemia and the risk of HIV infection in Lagos, Nigeria.


Int Conf AIDS. 1998;12:633 (abstract no. 33207). Unique Identifier :

BACKGROUND: Transfusion of blood and blood products is in important and frequent modality of treatment for either veno occlussive or anaemic crises in patients with sickle cell disease. We determine the relative risk of a patient with SCD seroconverting to HIV infection by comparing seroprevalence of HIV antibodies in transfused and non-transfused patients with haemoglobin genotype SS in Lagos. METHOD: One hundred and sixty (160) sickle cell anaemia patients who had received at least one point of blood in the last one year were recruited. Another eighty patients (age-matched) with confirmed Hb SS but who has never had blood transfusion served as the control group. The were all screened for HIV antibodies. Positive specimen were confirmed by Western blot. RESULTS: 6/160 (3.75%) of transfused patients were HIV seropositive. Age range was 5-9 years. None of the eighty in the control group was positive. CONCLUSION: HIV transmission through blood transfusion is very high in Nigeria. It is important that the issue of global blood safety initiative be emphasised particularly in developing countries.

MEETING ABSTRACTS Anemia, Sickle Cell/*THERAPY Blood Transfusion/*ADVERSE EFFECTS Child Child, Preschool Developing Countries Human HIV Infections/*ETIOLOGY/IMMUNOLOGY/PREVENTION & CONTROL/ TRANSMISSION *HIV Seroprevalence Mass Screening Matched-Pair Analysis Nigeria Risk Factors Urban Health


Information in this article was accurate in December 30, 1998. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.