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Hepatitis C virus (HCV) genotypes and progression of HIV infection in hemophiliacs.


Int Conf AIDS. 1998;12:147 (abstract no. 13306). Unique Identifier :

BACKGROUND: Hemophilia patients infused with non-heated plasma products were universally infected with HCV. HCV genotype 1 (HCV-1) is associated with poor response to interferon therapy, and it has been suggested that hemophilia patients infected with HCV-1 may experience a more rapid progression of HIV disease. The possible association between HCV-1 and HIV progression was assessed in HCV/HIV coinfected hemophilic subjects followed up within the Multicenter Hemophilia Cohort Study (MHCS). METHODS: Two hundred eighty-one hemophilic subjects with known HIV seroconversion dates were HCV genotyped by RT-PCR and reverse hybridization. Patients from US (n = 152) and Greece (n = 129) were included. AIDS and death risk were estimated by Kaplan-Meier and proportional hazards models, with left truncation for time before the HCV-genotyped sample. RESULTS: The distribution HCV genotypes was 62%, 10%, 11%, 4% and 3% for HCV-1, HCV-2, HCV-3, HCV-4 and mixed types respectively, while in 11% of the samples was not possible to determine the HCV genotype. The distribution was similar in the US and Greek patients. HCV-1 was associated with faster progression to AIDS or death (P = 0.0001 and P = 0.0009, respectively) in both countries. The relative hazard (95% CI, P) (adjusted for age at HIV seroconversion and country) for progressing to AIDS of HCV-1 infected patients vs others was 2.8 (1.5-5.2, P = 0.001). The relative hazard for death was found 2.3 (1.4-3.8, P = 0.001). CONCLUSION: HCV-1 is associated with faster progression to AIDS and death. This finding may have important implications for the treatment of HIV/HCV coinfected patients.

MEETING ABSTRACTS Acquired Immunodeficiency Syndrome/VIROLOGY Cohort Studies Disease Progression Genotype Hemophilia A/*COMPLICATIONS/VIROLOGY Hepatitis C/*COMPLICATIONS Hepatitis C-Like Viruses/*GENETICS Human HIV Infections/*COMPLICATIONS


Information in this article was accurate in December 30, 1998. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.