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NLM AIDSLINE

Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees.




 

Vaccine. 1998 Nov;16(19):1836-41. Unique Identifier : AIDSLINE

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

JOURNAL ARTICLE Animal AIDS Vaccines/ADVERSE EFFECTS/*IMMUNOLOGY/THERAPEUTIC USE Disease Models, Animal DNA, Viral/GENETICS/*IMMUNOLOGY Female HIV Antibodies/BLOOD HIV Infections/BLOOD/PREVENTION & CONTROL HIV-1/*GENETICS/*IMMUNOLOGY Lymphocyte Subsets/IMMUNOLOGY Male Pan troglodytes Pregnancy Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Vaccines, DNA/ADVERSE EFFECTS/*IMMUNOLOGY/THERAPEUTIC USE



 




Information in this article was accurate in March 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.