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Kaposi's sarcoma: a result of the interplay among inflammatory cytokines, angiogenic factors and viral agents.


Cytokine Growth Factor Rev. 1998 Mar;9(1):63-83. Unique Identifier :

Kaposi's sarcoma (KS) is an angioproliferative disease occurring in 4 clinic-epidemiologic forms. Although the AIDS-associated KS (AIDS-KS) is the most aggressive, all forms of KS share the same immunological and histopathological features suggesting common etiological and pathogenic factors. Recent data indicate that at least in early stage KS is not a real sarcoma but an angiohyperplastic-inflammatory lesion mediated by inflammatory cytokines and angiogenic factors, that is triggered or amplified by infection with human herpesvirus-8. In addition, the human immunodeficiency virus type-1 Tat protein appears to be responsible for the higher grade of aggressiveness of AIDS-KS as compared to the other forms of KS. However, given time, reactive KS may progress to a sarcoma as suggested by evidence of monoclonality in late-nodular lesions.

JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Angiogenesis Factor/*PHYSIOLOGY Animal Cytokines/*PHYSIOLOGY Herpesvirus, Kaposi Sarcoma-Associated/PHYSIOLOGY Human Inflammation/METABOLISM Sarcoma, Kaposi/IMMUNOLOGY/*METABOLISM/*PATHOLOGY/VIROLOGY Support, Non-U.S. Gov't Viral Proteins/*PHYSIOLOGY


Information in this article was accurate in July 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.