Trends Microbiol. 1998 Dec;6(12):496-500. Unique Identifier : AIDSLINE
Pattern recognition receptors of the innate and adaptive immune systems
apparently recognize unmethylated CpG motifs of bacterial DNA. Cells of
the innate immune system are activated directly by CpG motifs, and the
resulting response dictates a Th1 bias to the developing adaptive immune
response. Interestingly, antigen receptor occupancy of cells of the
adaptive immune system augments their responsiveness to CpG motifs,
suggesting that co-stimulatory mechanisms are operative.
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL Animal Antigen-Presenting
Cells/IMMUNOLOGY Bacterial Vaccines/IMMUNOLOGY CpG Islands DNA,
Bacterial/*IMMUNOLOGY Human Oligodeoxyribonucleotides/IMMUNOLOGY
Plasmids/IMMUNOLOGY Signal Transduction/IMMUNOLOGY Support, Non-U.S.
Gov't Th1 Cells/IMMUNOLOGY Vaccines, DNA/IMMUNOLOGY