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Immune modulation by the cholera-like enterotoxins: from adjuvant to therapeutic.


Immunol Today. 1999 Feb;20(2):95-101. Unique Identifier : AIDSLINE

Cholera toxin and its close relative, Escherichia coli heat-labile enterotoxin, are potent immunogens and mucosal adjuvants. The recent findings that their B subunits can promote tolerance highlights the complexity of their interactions with the immune system. Here, Neil Williams and colleagues review the mechanisms by which these molecules modulate leukocyte populations and seek to explain the paradox.

JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL *Adjuvants, Immunologic Animal Arthritis/IMMUNOLOGY/THERAPY Autoantigens/ADMINISTRATION & DOSAGE/IMMUNOLOGY Autoimmune Diseases/IMMUNOLOGY/THERAPY Bacterial Toxins/CHEMISTRY/*IMMUNOLOGY/METABOLISM/THERAPEUTIC USE Carbohydrate Sequence Cholera Toxin/CHEMISTRY/*IMMUNOLOGY/METABOLISM/THERAPEUTIC USE Collagen/IMMUNOLOGY Diabetes Mellitus, Insulin-Dependent/IMMUNOLOGY/THERAPY Encephalomyelitis, Allergic/IMMUNOLOGY/THERAPY Enterotoxins/CHEMISTRY/*IMMUNOLOGY/METABOLISM/THERAPEUTIC USE G(M1) Ganglioside/CHEMISTRY/METABOLISM Gene Expression Regulation/DRUG EFFECTS Hydrogen Bonding Immune Tolerance/*DRUG EFFECTS Interferon Type II/BIOSYNTHESIS/GENETICS Mice Mice, Inbred NOD Models, Molecular Molecular Sequence Data Protein Binding Protein Conformation Rats Structure-Activity Relationship Support, Non-U.S. Gov't Th2 Cells/IMMUNOLOGY


Information in this article was accurate in July 30, 1999. The state of the art may have changed since the publication date. This material is designed to support, not replace, the relationship that exists between you and your doctor. Always discuss treatment options with a doctor who specializes in treating HIV.