Arch Surg. 1999 May;134(5):540-4. Unique Identifier : AIDSLINE
BACKGROUND: Major surgery is known to suppress T-cell function; however,
its differential effects on the production of helper T-cell type 1
(T(H)1) and type 2 (T(H)2) cytokines remains unknown. OBJECTIVE: To
measure the production patterns of T(H)1 (interleukin 2 [IL-2] and
interferon gamma) and T(H)2 (IL-4 and IL-10) cytokines following major
surgery. DESIGN, SETTING, AND PATIENTS: A cohort study of patients (both
active and former members of the armed forces) at a military hospital.
INTERVENTION: Aortic surgery or carotid endarterectomy and measurement
of serum IL-6 levels by enzyme-linked immunosorbent assay. MAIN OUTCOME
MEASURES: Unstimulated and stimulated intracellular levels of IL-2,
IL-4, IL-10, and interferon gamma in CD4+, CD8+, and gammadelta+ T cells
and serum IL-6 levels immediately before and for 2 days after aortic
surgery or carotid endarterectomy. RESULTS: No unstimulated production
of T(H) or T(H)2 cytokines was detected. Stimulated intracellular levels
of IL-2 and interferon gamma were significantly depressed during the
postoperative period in all T-cell subsets in both patient groups. There
were no postoperative increases in stimulated IL-4 or IL-10 levels.
CONCLUSION: Major surgery suppresses the potential responses of T(H)1
cytokines without enhancing production of T(H)2 cytokines.
JOURNAL ARTICLE Aged Aorta/*SURGERY *Endarterectomy, Carotid Female
Human Interferon Type II/*BIOSYNTHESIS Interleukins/*BIOSYNTHESIS
Male Th1 Cells/*IMMUNOLOGY Th2 Cells/*IMMUNOLOGY