Am J Respir Crit Care Med. 1999 Jun;159(6):2014-7. Unique Identifier :
Globally, the proportion of all cases of tuberculosis (TB) caused by
drug-resistant strains is increasing. We report the case of a Canadian
citizen who acquired a highly drug-resistant strain of Mycobacterium
bovis while visiting a relative with AIDS-related tuberculosis in Spain.
The origin of the strain was traced using spoligotyping, a polymerase
chain reaction (PCR)-based fingerprint technology, and the European DNA
database. The level of primary drug resistance-all five first-line drugs
and 19 of 21 second-line drugs-in this case was unprecedented in Canada.
Isolation of this strain from a Canadian citizen represents the first
report of its appearance in this hemisphere. The infection was contained
and combined medical-surgical treatment delivered.
JOURNAL ARTICLE Acquired Immunodeficiency
Syndrome/COMPLICATIONS/TRANSMISSION Antibiotics/THERAPEUTIC USE Canada
Case Report Drug Therapy, Combination Female Human Middle Age
Mycobacterium bovis/*PHYSIOLOGY Radiography, Thoracic Support,
Non-U.S. Gov't Tomography, X-Ray Computed Tuberculosis Tuberculosis,
Multidrug-Resistant/COMPLICATIONS/DRUG THERAPY/ SURGERY/*TRANSMISSION
Tuberculosis, Pulmonary/COMPLICATIONS/DRUG THERAPY/SURGERY/